Ordering Recommendation

Aids in the diagnosis of C5 deficiency. May be used to investigate abnormal total complement activity.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red.

Specimen Preparation

Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Separator tubes. Specimens left to clot at 2-8°C. Specimens exposed to repeated freeze/thaw cycles. Nonfrozen specimens. Grossly hemolyzed or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 8 days; Frozen: 1 month

Methodology

Quantitative Immunoturbidimetry

Performed

Tue, Fri

Reported

1-7 days

Reference Interval

Test Number
Components
Reference Interval
  Complement C5, Functional 23.0 U/mL or greater

Interpretive Data




Component
Interpretation
Complement C5, Functional Low: 22.9 U/mL or less
Low-Normal: 23.0-28.3 U/mL
Normal: 28.4 U/mL or greater

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

86161

Components

Component Test Code* Component Chart Name LOINC
3005962 Complement C5, Functional 60472-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • anti-C5
  • C5 deficiency
  • C5 functional
  • C5 inhibitor
  • Complement blocking
  • Complement monitoring
  • Eculizumab
  • Ravulizumab
Complement C5, Functional